Dimethylamine → N,N-dimethyl-4-nitrobenzenesulfonamide

HRID 1883005

반응식

HRID 1883005 반응식
[CH3:1][NH:2][CH3:3].[N+:4]([C:7]1[CH:12]=[CH:11][C:10]([S:13](Cl)(=[O:15])=[O:14])=[CH:9][CH:8]=1)([O-:6])=[O:5]>CO>[CH3:1][N:2]([CH3:3])[S:13]([C:10]1[CH:9]=[CH:8][C:7]([N+:4]([O-:6])=[O:5])=[CH:12][CH:11]=1)(=[O:14])=[O:15]

참가 물질

4

반응물 2

HCID 674DimethylamineHCID 74044-Nitrobenzenesulfonyl chloride

생성물 1

HCID 2747580N,N-dimethyl-4-nitrobenzenesulfonamide수율 94.1%

시약·촉매·용매 1

HCID 887Methanol용매

실험 절차

To a stirring solution of dimethylamine (180 mL, 40% in water, 1.57 mol) in methanol (180 mL) at 0° C., was slowly added 4-nitrobenzenesulfonyl chloride (69.5 g, 314 mmol). After complete addition, the cold bath was removed; and, after stirring overnight, the mixture was filtered and the precipitate was washed with water and dried in vacuo to give 68 g (94%) of tan solid.

후처리

  1. customat 0° C.
  2. additionAfter complete addition
  3. customthe cold bath was removed
  4. filtrationthe mixture was filtered
  5. washthe precipitate was washed with water
  6. customdried in vacuo

출처 및 근거

ORD 기록
ord-2b3e42496ca04bdda12d65ce190745c0
출처 데이터셋
uspto-grants-2004_07
특허 번호
US06759414B2

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