Methanol → HCID 505741, 화합물

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CO.[CH3:3][NH2:4].C(O[C:8]([C:10]1[C:11]([NH:18][C:19]2[CH:20]=[C:21]3[C:25](=[CH:26][CH:27]=2)[NH:24][N:23]=[CH:22]3)=[N:12][C:13]([S:16][CH3:17])=[N:14][CH:15]=1)=[O:9])C>O>[NH:24]1[C:25]2[C:21](=[CH:20][C:19]([NH:18][C:11]3[C:10]([C:8]([NH:4][CH3:3])=[O:9])=[CH:15][N:14]=[C:13]([S:16][CH3:17])[N:12]=3)=[CH:27][CH:26]=2)[CH:22]=[N:23]1

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온도: 22.5 °C

실험 절차

To the solution of methanol with 40% methylamine (30 ml) was added 4-(1H-5-indazolylamino)-2-methylthio-5-pyrimidine carboxylic acid ethyl ester (1.5 g) obtained by by preparation example 1, and the solution was reacted at 25-30° C. for 1 hr. The reaction mixture was cooled at 20-25° C., added H2O (90 ml) and stirred for 0.5hr. The reaction mixture was filtered, washed with 25% aqueous methanol solution (10 ml), obtained a solid product. The solid product was dried in vacuo to obtain the desired compound (1.26 g, 88%).