Trifluoroacetic acid → HCID 69758844, 화합물

HRID 1883648노트

반응식

HRID 1883648 반응식
[NH2:1][C:2]1[CH:14]=[CH:13][C:5]([C:6]([O:8]C(C)(C)C)=[O:7])=[CH:4][C:3]=1[CH2:15][NH:16][C:17](=[O:20])[CH2:18][CH3:19].[C:21]([OH:27])([C:23]([F:26])([F:25])[F:24])=[O:22]>C(Cl)Cl>[F:24][C:23]([F:26])([F:25])[C:21]([OH:27])=[O:22].[NH2:1][C:2]1[CH:14]=[CH:13][C:5]([C:6]([OH:8])=[O:7])=[CH:4][C:3]=1[CH2:15][NH:16][C:17](=[O:20])[CH2:18][CH3:19]

참가 물질

4

반응물 2

HCID 6422Trifluoroacetic acidHCID 69911586HCID 69911586, 화합물

생성물 1

HCID 69758844HCID 69758844, 화합물

시약·촉매·용매 1

HCID 6344Dichloromethane용매

실험 절차

To a solution of t-butyl 4-amino-3-[(N-methylacetylamino)methyl]benzoate (2.13 g, 7.65 mmole) in CH2Cl2 (150 mL) at RT was added TFA (30 mL). After 12 hr, the reaction solution was concentrated to an oil and dried under high vacuum overnight. The resulting residue was washed with hexanes and Et2O to afford the title compound (2.56 g, 7.60 mmole) as an off-white solid. This compound was used without further purification: MS (ES) m/e 223 (M+H-TFA)+.

후처리

  1. concentrationthe reaction solution was concentrated to an oil
  2. customdried under high vacuum overnight
  3. washThe resulting residue was washed with hexanes and Et2O

출처 및 근거

ORD 기록
ord-6aa400d9f65c45779b865b33c03a3670
출처 데이터셋
uspto-grants-2004_07
특허 번호
US06762201B1

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