HCID 23508505, 화합물 → HCID 23508424, 화합물

HRID 1883670노트

반응식

HRID 1883670 반응식
[CH3:1][S:2]([O:5][C:6]1[CH:11]=[CH:10][C:9]([N:12]([CH2:17][C:18]2[CH:23]=[CH:22][C:21]([O:24]CC3C=CC=CC=3)=[CH:20][CH:19]=2)[S:13]([CH3:16])(=[O:15])=[O:14])=[CH:8][CH:7]=1)(=[O:4])=[O:3].[H][H]>[C].[Pd].O1CCOCC1>[CH3:1][S:2]([O:5][C:6]1[CH:11]=[CH:10][C:9]([N:12]([CH2:17][C:18]2[CH:19]=[CH:20][C:21]([OH:24])=[CH:22][CH:23]=2)[S:13]([CH3:16])(=[O:15])=[O:14])=[CH:8][CH:7]=1)(=[O:3])=[O:4]

참가 물질

5

반응물 2

HCID 23508505HCID 23508505, 화합물HCID 178418361HCID 178418361, 화합물

생성물 1

HCID 23508424HCID 23508424, 화합물수율 92.3%

시약·촉매·용매 2

HCID 178418390HCID 178418390, 화합물촉매HCID 312751,4-Dioxane용매

실험 절차

A mixture composed of 350 mg of 4-[N-(4-benzyloxybenzyl)-N-methylsulfonylamino]phenyl methanesulfonate, 350 mg of 10% palladium-carbon, and 10 ml of dioxane was stirred for 2 days under an atmospheric pressure of hydrogen. The reaction mixture was filtered to remove any insoluble matter, and the solvent was distilled off from the filtrate. Thus, there was obtained 260 mg of 4-[N-(4-hydroxybenzyl)-N-methylsulfonylamino]phenyl methanesulfonate.

후처리

  1. filtrationThe reaction mixture was filtered
  2. customto remove any insoluble matter
  3. distillationthe solvent was distilled off from the filtrate

출처 및 근거

ORD 기록
ord-e709158e422a405eaf229008c5119fb2
출처 데이터셋
uspto-grants-2004_07
특허 번호
US06762205B1

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