참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | Chloroacetamide | HCID 6580 | — |
| 반응물 | Potassium Carbonate | HCID 11430 | — |
| 반응물 | tert-Butyl 4-(3-formyl-4-hydroxyphenyl)piperazine-1-carboxylate | HCID 23508726 | — |
| 용매 | N-methyl-2-pyrrolidone | HCID 13387 | — |
| 생성물 | Tert-butyl 4-(2-carbamoylbenzofuran-5-yl)piperazine-1-carboxylate | HCID 11244883 | — |
반응 단계
5 ml of 1-methyl-2-pyrrolidone, 0.16 g of chloroacetamide and 0.25 g of potassium carbonate are added at 20° C. with stirring/under nitrogen to 0.5 g of 5-(4-tert-butoxycarbonylpiperazin-1-yl)-2-hydroxybenzaldehyde. The mixture is stirred at 60° C. for 16 hours, cooled and then filtered, and the solvent is removed under reduced pressure. The residue is taken up in MTB ether, re-filtered and concentrated, and the residue is crystallized from toluene. The isolated yield is 0.34 g (60%).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 특허 번호 | US06762300B2 |
|---|
| 출처 데이터셋 | uspto-grants-2004_07 |
|---|
| ORD ID | ord-18960a06f803452e8e3f8345adf75c2b |
|---|
| 출처 메모 | uspto-grants-2004_07 |
|---|
