Benzaldehyde → 2-Methyl-N-(phenylmethylene)-2-propanamine

HRID 1884078

반응식

HRID 1884078 반응식
[C:1]1([CH:7]=[N+:8]([C:10]([CH3:13])([CH3:12])[CH3:11])[O-])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.C(=O)C1C=CC=CC=1.C(N)(C)(C)C>O>[CH:7](=[N:8][C:10]([CH3:13])([CH3:12])[CH3:11])[C:1]1[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1

참가 물질

5

반응물 3

HCID 240BenzaldehydeHCID 4390N-tert-Butyl-a-phenylnitroneHCID 6385Tert-Butylamine

생성물 1

HCID 1112402-Methyl-N-(phenylmethylene)-2-propanamine

시약·촉매·용매 1

HCID 962Water용매

실험 절차

The imine starting material may be commercially purchased or synthetically prepared. If desired, the imine may be prepared by a condensation reaction between an aldehyde and a primary amine. In one embodiment of the present invention, the imine precursor for α-phenyl-N-tert-butyl nitrone (PBN) is prepared by combining benzaldehyde and t-butyl amine at room temperature, in the absence of a solvent, to form the corresponding benzylidene-t-butyl amine (imine) and water. It was found that the resulting imine was sufficiently pure for use in the next step without the need for purification or removal of water by-product contained therein. Thus, the present method reduces time and cost, and improves efficiency, in comparison with traditional transformations.

후처리

  1. customsynthetically prepared
  2. customat room temperature

출처 및 근거

ORD 기록
ord-011a1c48d53549779cefa04ca71b5e75
출처 데이터셋
uspto-grants-2004_07
특허 번호
US06762322B1

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