Potassium Iodide → L82Nub8C3A

HRID 18844

반응식

HRID 18844 반응식
Br[CH2:2][C:3]1[CH:8]=[CH:7][C:6]([C:9]2[CH:14]=[CH:13][CH:12]=[CH:11][C:10]=2[C:15]#[N:16])=[CH:5][CH:4]=1.[CH3:17][O:18][C:19](=[O:25])[C@H:20]([CH:22]([CH3:24])[CH3:23])[NH2:21].[C:26](=[O:29])([O-:28])[O-].[K+].[K+].[I-].[K+]>C(#N)C>[C:19]([OH:25])(=[O:18])[C:26]([OH:28])=[O:29].[CH3:17][O:18][C:19](=[O:25])[C@H:20]([CH:22]([CH3:24])[CH3:23])[NH:21][CH2:2][C:3]1[CH:8]=[CH:7][C:6]([C:9]2[CH:14]=[CH:13][CH:12]=[CH:11][C:10]=2[C:15]#[N:16])=[CH:5][CH:4]=1

참가 물질

6

반응물 4

HCID 4875Potassium IodideHCID 11430Potassium CarbonateHCID 94285Valine methyl esterHCID 15019124'-(Bromomethyl)-2-cyanobiphenyl

생성물 1

HCID 51050401L82Nub8C3A

시약·촉매·용매 1

HCID 6342Acetonitrile용매

반응 조건

온도
42.5 °C

실험 절차

In one of the preferred embodiments 4-bromomethyl-2′-cyanobiphenyl, L-valine methyl ester, potassium carbonate and potassium iodide are taken in acetonitrile. The reaction mixture was stirred at about 40-45° C. for about 3 to 4 hours and the solvent was removed under vacuum. Water and xylene was added to reaction mass and the organic layer was separated. A solution of oxalic acid was added to the organic layer and stirred for about an hour at ambient temperature to give N-[(2′-cyanobiphenyl-4-yl)methyl]-(L)-valine methyl ester oxalate salt.

후처리

  1. customthe solvent was removed under vacuum
  2. additionWater and xylene was added to reaction mass
  3. customthe organic layer was separated
  4. additionA solution of oxalic acid was added to the organic layer
  5. stirringstirred for about an hour at ambient temperature

출처 및 근거

ORD 기록
ord-d17d76d5bf9d49e0bd43c815da86fdef
출처 데이터셋
uspto-grants-2010_06
특허 번호
US07741507B2

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