Tetrahydrofuran → 2-[(R)-3-decanoyloxytetradecanoylamino]ethanol
반응식
[C:1]([O:12][C@H:13]([CH2:18][CH2:19][CH2:20][CH2:21][CH2:22][CH2:23][CH2:24][CH2:25][CH2:26][CH2:27][CH3:28])[CH2:14][C:15]([OH:17])=O)(=[O:11])[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][CH3:10].C(Cl)CCl.CI.CC[CH2:37][CH2:38][N+:39](CCCC)(CCCC)CCCC.[F-].C1C[O:56]CC1>>[C:1]([O:12][C@H:13]([CH2:18][CH2:19][CH2:20][CH2:21][CH2:22][CH2:23][CH2:24][CH2:25][CH2:26][CH2:27][CH3:28])[CH2:14][C:15]([NH:39][CH2:38][CH2:37][OH:56])=[O:17])(=[O:11])[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][CH3:10]참가 물질
5
실험 절차
In the same manner as described in Example 20-(1), 2-amino-1-(t-butyldiphenylsilyloy)ethane (450 mg, 1.5 mmol) was acylated with (R)-3-decanoyloxytetradecanoic acid (600 mg, 1.5 mmol) in the presence of EDC MeI (594 mg, 2.0 mmol) and then deprotected with TBAF (1.0 M in THF, 2.5 mL, 2.5 mmol) in THF (10 mL) to afford 488 mg (81%) of 2-[(R)-3-decanoyloxytetradecanoylamino]ethanol as an off-white solid.