Diphenyl Ether → 3-butyryl-8-acetyl-4(1H)-quinolone

HRID 1885172

반응식

HRID 1885172 반응식
[C:1]([C:6](=[CH:12][NH:13][C:14]1[CH:19]=[CH:18][CH:17]=[CH:16][C:15]=1[C:20](=[O:22])[CH3:21])[C:7]([O:9]CC)=O)(=[O:5])[CH2:2][CH2:3][CH3:4].C1(OC2C=CC=CC=2)C=CC=CC=1>CCOCC>[C:1]([C:6]1[C:7](=[O:9])[C:19]2[C:14](=[C:15]([C:20](=[O:22])[CH3:21])[CH:16]=[CH:17][CH:18]=2)[NH:13][CH:12]=1)(=[O:5])[CH2:2][CH2:3][CH3:4]

참가 물질

4

반응물 2

HCID 7583Diphenyl EtherHCID 178450482HCID 178450482, 화합물

생성물 1

HCID 103777553-butyryl-8-acetyl-4(1H)-quinolone수율 70.1%

시약·촉매·용매 1

HCID 3283Diethyl Ether용매

실험 절차

Ethyl 2-butyryl-3-(2-acetylphenylamino)acrylate (14.8 g, 48.8 mmol) was added to boiling diphenyl ether (50 ml) and heated at reflux for 3.5 hours. After cooling, the solution was poured into ether, and the solid filtered off and washed with ether to obtain 3-butyryl-8-acetyl-4(1H)-quinolone (8.8 g), contaminated with some diphenyl ether. This material was used without further purification.

후처리

  1. temperatureheated
  2. temperatureat reflux for 3.5 hours
  3. temperatureAfter cooling
  4. filtrationthe solid filtered off
  5. washwashed with ether

출처 및 근거

ORD 기록
ord-b0f96a80b7ba468191ba8632e0f3bb51
출처 데이터셋
uspto-grants-1992_09
특허 번호
US05143920

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