Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Dimethyl Sulfide → 2-Methyl-1-phenyl-1-propanol
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Dimethyl Sulfide | HCID 1068 | — |
| 반응물 | Triglyme | HCID 8189 | — |
| 반응물 | Ethyl sulfide | HCID 9609 | — |
| 반응물 | Phenylpropanolamine Hydrochloride | HCID 62943 | — |
| 반응물 | Isobutyrophenone | HCID 69144 | — |
| 반응물 | (E)-1-(2,4-dichlorophenyl)-2-(1,2,4-triazol-1-yl)-4,4-dimethyl-1-penten-3-one | HCID 11110117 | — |
| 용매 | 1,2-Dichloroethane | HCID 11 | — |
| 용매 | Dimethylformamide | HCID 6228 | — |
| 용매 | Chlorobenzene | HCID 7964 | — |
| 생성물 | 2-Methyl-1-phenyl-1-propanol | HCID 95626 | 97.2% |
반응 단계
The same procedure as in Example 1 was repeated except that (+)-norephedrine hydrochloride was replaced by (-)-norephedrine hydrochloride, triglyme was replaced by 0.4 ml of dimethylformamide, dimethyl sulfide was replaced by diethyl sulfide, monochlorobenzene was replaced by 1,2-dichloroethane, (E)-1-(2,4-dichlorophenyl)-2-(1,2,4-triazol-1-yl)-4,4-dimethyl-1-penten-3-one was replaced by 0.27 g (1.85 mmoles) of phenyl isopropyl ketone, and the reduction reaction was conducted for 18.5 hours, to obtain 0.27 g of crude (-)-phenylisobutyl alcohol.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US05144039 |
| 출처 데이터셋 | uspto-grants-1992_09 |
| ORD ID | ord-ac302dae37ed47baba21ba0f22a696a4 |
| 출처 메모 | uspto-grants-1992_09 |