p-Toluenesulfonic acid → HCID 15228403, 화합물

HRID 1885602노트

반응식

HRID 1885602 반응식
[Cl:1][C:2]1[CH:3]=[C:4]([S:9][CH2:10][CH:11]([CH2:15][CH2:16][C:17]([OH:19])=[O:18])[C:12]([OH:14])=[O:13])[CH:5]=[CH:6][C:7]=1[Cl:8].[C:20]1(C)C=CC(S(O)(=O)=O)=CC=1>CO>[Cl:1][C:2]1[CH:3]=[C:4]([S:9][CH2:10][CH:11]([CH2:15][CH2:16][C:17]([O:19][CH3:20])=[O:18])[C:12]([OH:14])=[O:13])[CH:5]=[CH:6][C:7]=1[Cl:8]

참가 물질

4

반응물 2

HCID 6101p-Toluenesulfonic acidHCID 198793472-{[(3,4-Dichlorophenyl)sulfanyl]methyl}pentanedioic acid

생성물 1

HCID 15228403HCID 15228403, 화합물수율 1,656.8%

시약·촉매·용매 1

HCID 887Methanol용매

반응 조건

온도
40 °C

실험 절차

A mixture of 2-(3,4-dichlorophenylthiomethyl)glutaric acid (3.00 g), methanol (30 ml), and p-toluenesulfonic acid (0.09 g) was stirred at 40° C. for 2.5 hours. The reaction mixture was concentrated in vacuo, and the resulting residue was purified by flash column chromatography on silica by eluting with chloroform/ethanol (10:1) to give 2.92 g of 3-(3,4-dichlorophenylthio)-2-(2-methoxycarbonylethyl)propionic acid as an oil.

후처리

  1. concentrationThe reaction mixture was concentrated in vacuo
  2. customthe resulting residue was purified by flash column chromatography on silica
  3. washby eluting with chloroform/ethanol (10:1)

출처 및 근거

ORD 기록
ord-d33357b1d12e4b5994000da56ddcd000
출처 데이터셋
uspto-grants-1992_09
특허 번호
US05145869

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