Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Sulfuric Acid → Methyl 2-(2-[4-fluorophenyl]ethyl)phenylacetate
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Sulfuric Acid | HCID 1118 | — |
| 반응물 | Benzyl Chloride | HCID 7503 | — |
| 반응물 | Phenylacetonitrile | HCID 8794 | — |
| 반응물 | Potassium Cyanide | HCID 9032 | — |
| 반응물 | 4-Fluorobenzaldehyde | HCID 68023 | — |
| 반응물 | Phenylacetate | HCID 4409936 | — |
| 반응물 | {[2-(Methoxycarbonyl)phenyl]methyl}(triphenyl)phosphanium bromide | HCID 10743695 | — |
| 반응물 | Methyl 2-[2-(2-furyl)ethyl]phenylacetate | HCID 19879669 | — |
| 용매 | Dimethyl Sulfoxide | HCID 679 | — |
| 용매 | Methanol | HCID 887 | — |
| 생성물 | Methyl 2-(2-[4-fluorophenyl]ethyl)phenylacetate | HCID 19879670 | — |
반응 단계
Methyl 2-(2-[4-fluorophenyl]ethyl)phenylacetate was prepared from 4-fluorobenzaldehyde and (o-methoxycarbonylbenzyl)triphenylphosphonium bromide by a route similar to that described in Example 3 for the preparation of methyl 2-[2-(2-furyl)ethyl]phenylacetate. In this instance, the benzyl chloride was converted into the phenylacetate by treatment with potassium cyanide in DMSO and, then, methanolysis of the resulting phenylacetonitrile with sulphuric acid in methanol.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US05145954 |
| 출처 데이터셋 | uspto-grants-1992_09 |
| ORD ID | ord-51a733eb0d084f3f86d134e975174bbe |
| 출처 메모 | uspto-grants-1992_09 |