Methanol → 1-amino-3-propyl-5-hydroxyhexahydrocyclopenta[d]imidazole-2(1H)-one

HRID 1885899노트

반응식

HRID 1885899 반응식
C(=[N:8][N:9]1[CH:13]2[CH2:14][CH:15]([OH:17])[CH2:16][CH:12]2[N:11]([CH2:18][CH2:19][CH3:20])[C:10]1=[O:21])C1C=CC=CC=1.CO>[Pd].C(O)(=O)C>[NH2:8][N:9]1[CH:13]2[CH2:14][CH:15]([OH:17])[CH2:16][CH:12]2[N:11]([CH2:18][CH2:19][CH3:20])[C:10]1=[O:21]

참가 물질

5

반응물 2

HCID 887MethanolHCID 679048761-Benzylideneamino-3-propyl-5-hydroxyhexahydrocylopenta[d]imidazol-2(1H)-one

생성물 1

HCID 198784021-amino-3-propyl-5-hydroxyhexahydrocyclopenta[d]imidazole-2(1H)-one수율 103%

시약·촉매·용매 2

HCID 23938Palladium촉매HCID 176Acetic Acid용매

반응 조건

온도
15 °C

실험 절차

The compound of step (f) (7.0 g) was added to a solution of methanol (280 ml) and acetic acid (2.25 ml) containing 10% Pd on carbon (2.5 g) and the resulting mixture stirred at 15° C. under an atmosphere of hydrogen for 3 days. The catalyst was removed by filtration through Celite and concentration of the filtrate in vacuo gave the desired product as an oil (5.0 g).

후처리

  1. customThe catalyst was removed by filtration through Celite and concentration of the filtrate in vacuo

출처 및 근거

ORD 기록
ord-a2063fc0b2c143bfb121119341426eab
출처 데이터셋
uspto-grants-1992_09
특허 번호
US05147885

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