홈MCP워크벤치Skills
홈워크벤치알림마이페이지
llms.txt · MCP 가이드개인정보처리방침 · 이용약관 · 지원v1.8.0
  1. 홈
  2. /반응

Sodium Acetate → 5-Hydroxy-1-(2-cyclohexyl-2-acetoxyethylideneamino)-3-propylhexahydrocyclopenta[d]imidazole-2(1H)-one

HRID 1885900
노트
인쇄 미리보기

반응식

HRID 1885900 반응식
[NH2:1][N:2]1[CH:6]2[CH2:7][CH:8]([OH:10])[CH2:9][CH:5]2[N:4]([CH2:11][CH2:12][CH3:13])[C:3]1=[O:14].[C:15]([O:18][CH:19]([CH:22]1[CH2:27][CH2:26][CH2:25][CH2:24][CH2:23]1)[CH:20]=O)(=[O:17])[CH3:16].C([O-])(=O)C.[Na+]>CO>[OH:10][CH:8]1[CH2:7][CH:6]2[N:2]([N:1]=[CH:20][CH:19]([CH:22]3[CH2:27][CH2:26][CH2:25][CH2:24][CH2:23]3)[O:18][C:15](=[O:17])[CH3:16])[C:3](=[O:14])[N:4]([CH2:11][CH2:12][CH3:13])[CH:5]2[CH2:9]1
참가 물질반응 조건실험 절차후처리출처 및 근거반응 노트

참가 물질

5

반응물 3

HCID 517045Sodium AcetateHCID 109869602-Cyclohexyl-2-acetoxyacetaldehydeHCID 198784021-amino-3-propyl-5-hydroxyhexahydrocyclopenta[d]imidazole-2(1H)-one

생성물 1

HCID 543417855-Hydroxy-1-(2-cyclohexyl-2-acetoxyethylideneamino)-3-propylhexahydrocyclopenta[d]imidazole-2(1H)-one수율 117.8%

시약·촉매·용매 1

HCID 887Methanol
용매

반응 조건

온도
15 °C

실험 절차

A solution of the compound of step (g) (5.0 g) and 2-acetoxy-2-cyclohexylacetaldehyde (Ross et al, J. Med. Chem., 22, 412 (1979), 6.0 g) in methanol (175 ml) containing sodium acetate (3.64 g) was stirred at 15° C. under a nitrogen atmosphere for 16 hours. The alcohol was removed in vacuo and water (100 ml) and chloroform (100 ml) added. The organic phase was separated and washed with brine (100 ml), then dried over anhy. sodium sulphate. Filtration and concentration of the filtrate in vacuo gave a yellow oil (10.8 g).

후처리

  1. customThe alcohol was removed in vacuo and water (100 ml) and chloroform (100 ml)
  2. additionadded
  3. customThe organic phase was separated
  4. washwashed with brine (100 ml)
  5. customdried over anhy
  6. filtrationFiltration and concentration of the filtrate in vacuo

출처 및 근거

ORD 기록
ord-8b4f97a634b142dd8f84a9e8803c0ffd
출처 데이터셋
uspto-grants-1992_09
DOI
10.6084/m9.figshare.5104873.v1
특허 번호
US05147885

반응 노트

불러오는 중…

이 페이지에서참가 물질반응 조건실험 절차후처리출처 및 근거반응 노트