Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Trifluoroacetic acid → 1-Benzyl-3-(trifluoromethyl)pyrrolidine-3-carboxylic acid
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Trifluoroacetic acid | HCID 6422 | — |
| 반응물 | Benzyl(methoxymethyl)((trimethylsilyl)methyl)amine | HCID 353442 | — |
| 반응물 | 2-(Trifluoromethyl)acrylic acid | HCID 587694 | — |
| 용매 | Dichloromethane | HCID 6344 | — |
| 생성물 | 1-Benzyl-3-(trifluoromethyl)pyrrolidine-3-carboxylic acid | HCID 19691367 | — |
반응 단계
A 2.48 g sample of 2-(trifluoromethyl)acrylic acid was dissolved in 40 mL of dry methylene chloride, and a solution of 4.75 g of N-benzyl-N-(methoxymethyl)-trimethylsilylmethylamine in 20 mL of dry methylene chloride was added dropwise under N2 at 0° C. To this mixture was added 2 mL of trifluoroacetic acid, and the mixture was stirred for 2 hours at room temperature. The product was removed by filtration, washed and dried to give the title product.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US05726182 |
| 출처 데이터셋 | uspto-grants-1998_03 |
| ORD ID | ord-7b48bd4f78a1409eb2c2a20f041bf0c4 |
| 출처 메모 | uspto-grants-1998_03 |