6-(2-Pyrimidinyl)-5-hexynol → 6-(Pyrimidin-2-YL)hexan-1-OL

HRID 1886012노트

반응식

HRID 1886012 반응식
[N:1]1[CH:6]=[CH:5][CH:4]=[N:3][C:2]=1[C:7]#[C:8][CH2:9][CH2:10][CH2:11][CH2:12][OH:13]>C(O)C.[Pd]>[N:1]1[CH:6]=[CH:5][CH:4]=[N:3][C:2]=1[CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][CH2:12][OH:13]

참가 물질

4

반응물 1

HCID 198767486-(2-Pyrimidinyl)-5-hexynol

생성물 1

HCID 198767736-(Pyrimidin-2-YL)hexan-1-OL수율 29.4%

시약·촉매·용매 2

HCID 23938Palladium촉매HCID 702Ethanol용매2회

실험 절차

A solution of 6-(2-pyrimidinyl)-5-hexynol (3.09 g) in ethanol (100 ml) was added to a pre-hydrogenated suspension of 10% palladium on charcoal (1.05 g) in ethanol (50 ml) and hydrogenated at room temperature and pressure, filtered and evaporated in vacuo. The residual oil was purified by FCC eluting with ether and System C (99:1-85:15) to give the title compound as a pale yellow oil (0.93 g).

후처리

  1. filtrationpressure, filtered
  2. customevaporated in vacuo
  3. customThe residual oil was purified by FCC
  4. washeluting with ether and System C (99:1-85:15)

출처 및 근거

ORD 기록
ord-4ab2a6f5eed9480ca3382287c4069849
출처 데이터셋
uspto-grants-1992_09
특허 번호
US05149698

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