1,6-Dibromohexane → HCID 19876761, 화합물
반응식
[CH3:1][C:2]1[S:3][CH:4]=[C:5]([CH2:7][CH2:8][OH:9])[N:6]=1.[Br:10][CH2:11][CH2:12][CH2:13][CH2:14][CH2:15][CH2:16]Br>O>[Br:10][CH2:11][CH2:12][CH2:13][CH2:14][CH2:15][CH2:16][O:9][CH2:8][CH2:7][C:5]1[N:6]=[C:2]([CH3:1])[S:3][CH:4]=1참가 물질
4
실험 절차
A mixture of 2-methyl-4-thiazoleethanol (2.22 g), 1,6-dibromohexane (7.1 ml) 12.5M aqueous sodium hydroxide (4 ml) and TAB (0.1 g) was stirred rapidly at room temperature for 16 h. The reaction mixture was diluted with water (30 ml), extracted with ether (3×30 ml) and the combined organic extracts were washed with water (30 ml) and brine (30 ml), dried and concentrated. The residual oil was purified by FCC eluting with diethyl ether-hexane (1:3) to give the title compound as an orange oil (2.21 g), t.l.c. (ether-hexane 1:3) Rf 0.17
후처리
- extractionextracted with ether (3×30 ml)
- washthe combined organic extracts were washed with water (30 ml) and brine (30 ml)
- customdried
- concentrationconcentrated
- customThe residual oil was purified by FCC
- washeluting with diethyl ether-hexane (1:3)
출처 및 근거
- ORD 기록
- ord-61af359a52464286bebb9a9858be5a41
- 출처 데이터셋
- uspto-grants-1992_09
- 특허 번호
- US05149698
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