[6-[(6-Bromohexyl)oxy]-1-hexynyl]pyrazine → [6-[(6-Bromohexyl)oxy]hexyl]pyrazine

HRID 1886028노트

반응식

HRID 1886028 반응식
[Br:1][CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][O:8][CH2:9][CH2:10][CH2:11][CH2:12][C:13]#[C:14][C:15]1[CH:20]=[N:19][CH:18]=[CH:17][N:16]=1>C(O)C.[Pd]>[Br:1][CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][O:8][CH2:9][CH2:10][CH2:11][CH2:12][CH2:13][CH2:14][C:15]1[CH:20]=[N:19][CH:18]=[CH:17][N:16]=1

참가 물질

4

반응물 1

HCID 19876775[6-[(6-Bromohexyl)oxy]-1-hexynyl]pyrazine

생성물 1

HCID 19876745[6-[(6-Bromohexyl)oxy]hexyl]pyrazine수율 87.7%

시약·촉매·용매 2

HCID 23938Palladium촉매HCID 702Ethanol용매2회

실험 절차

A solution of [6-[(6-bromohexyl)oxy]-1-hexynyl]pyrazine (2.76 g) in ethanol (70 ml) was added to a pre-hydrogenated suspension of 10% palladium on carbon (2.00 g) in ethanol (50 ml) and hydrogenated at room temperature and pressure for 11 h. The mixture was filtered through hyflo and evaporated in vacuo to afford the title compound as a colourless oil (2.45 g), t.l.c. (ether) Rf 0.55.

후처리

  1. filtrationThe mixture was filtered through hyflo
  2. customevaporated in vacuo

출처 및 근거

ORD 기록
ord-63bc457d41ff46f29a159da37cc68b84
출처 데이터셋
uspto-grants-1992_09
특허 번호
US05149698

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