Nitric Acid → 6-Amino-5-fluoro-2,3-dihydro-1,3-benzoxazol-2-one

HRID 1886149노트

반응식

HRID 1886149 반응식
[F:1][C:2]1[CH:3]=[CH:4][C:5]2[O:9][C:8](=[O:10])[NH:7][C:6]=2[CH:11]=1.[N+:12]([O-])(O)=O>>[NH2:12][C:3]1[C:2]([F:1])=[CH:11][C:6]2[NH:7][C:8](=[O:10])[O:9][C:5]=2[CH:4]=1

참가 물질

3

반응물 2

HCID 944Nitric AcidHCID 2872085-Fluoro-2(3H)-benzoxazolone

생성물 1

HCID 156759596-Amino-5-fluoro-2,3-dihydro-1,3-benzoxazol-2-one

반응 조건

온도
50 °C

실험 절차

To a stirred solution of 300 ml concentrated nitric acid, at room temperature, was added portionwise 73.2 g (0.48 mole) of 5-fluoro-2(3H)-benzoxazolone. The reaction mixture was warmed to 50° C., and was stirred for 4 hours. After cooling, the reaction mixture was poured onto ice. The precipitate which formed was collected, washed with water, and dried to give 72.8 g of the title compound as a brown powder: m.p. 207°-209° C.

후처리

  1. temperatureAfter cooling
  2. additionthe reaction mixture was poured onto ice
  3. customThe precipitate which formed
  4. customwas collected
  5. washwashed with water
  6. customdried

출처 및 근거

ORD 기록
ord-542807daf5c94e64b336f0a6facf2403
출처 데이터셋
uspto-grants-1992_09
특허 번호
US05149821

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