5-Fluoro-6-nitro-2,3-dihydro-1,3-benzoxazol-2-one → 6-Amino-5-fluoro-2,3-dihydro-1,3-benzoxazol-2-one

HRID 1886150

반응식

HRID 1886150 반응식
[F:1][C:2]1[C:3]([N+:12]([O-])=O)=[CH:4][C:5]2[O:9][C:8](=[O:10])[NH:7][C:6]=2[CH:11]=1>O1CCCC1.[C].[Pd]>[NH2:12][C:3]1[C:2]([F:1])=[CH:11][C:6]2[NH:7][C:8](=[O:10])[O:9][C:5]=2[CH:4]=1

참가 물질

4

반응물 1

HCID 112178355-Fluoro-6-nitro-2,3-dihydro-1,3-benzoxazol-2-one

생성물 1

HCID 156759596-Amino-5-fluoro-2,3-dihydro-1,3-benzoxazol-2-one수율 107.7%

시약·촉매·용매 2

HCID 178418390HCID 178418390, 화합물촉매HCID 8028Tetrahydrofuran용매2회

실험 절차

To a solution of 5-fluoro-6-nitro-2(3H)-benzoxazolone (20 g, 0.1 mole) in 300 ml tetrahydrofuran was added 2 g palladium carbon (5%) under nitrogen atmosphere. The mixture was hydrogenated with a Parr shaker for 10 hours at 45 psi. The precipitate which resulted from hydrogenation was redissolved by adding tetrahydrofuran. The catalyst was removed by filtration and the filtrate was concentrated to give 18.1 g of the title compound as a brown solid: m.p. 180°-182° C. (dec.).

후처리

  1. customThe precipitate which resulted from hydrogenation
  2. dissolutionwas redissolved
  3. customThe catalyst was removed by filtration
  4. concentrationthe filtrate was concentrated

출처 및 근거

ORD 기록
ord-8c23a550a38c457c85ee5b7ec5c093fb
출처 데이터셋
uspto-grants-1992_09
특허 번호
US05149821

연결된 노트

불러오는 중…