Triphosphate → 1-(2-Hydroxyethoxymethyl)5-(3-amino-1-propynyl)cytosine

HRID 1886515노트

반응식

HRID 1886515 반응식
[OH:1][CH2:2][CH2:3][O:4][CH2:5][N:6]1[CH:13]=[C:12]([C:14]#[C:15][CH2:16][NH:17]C(=O)C(F)(F)F)[C:10]([NH2:11])=[N:9][C:7]1=[O:8].[O-]P(OP(OP([O-])([O-])=O)([O-])=O)(=O)[O-]>>[OH:1][CH2:2][CH2:3][O:4][CH2:5][N:6]1[CH:13]=[C:12]([C:14]#[C:15][CH2:16][NH2:17])[C:10]([NH2:11])=[N:9][C:7]1=[O:8]

참가 물질

3

반응물 2

HCID 3440921TriphosphateHCID 199580181-(2-Hydroxyethoxymethyl)-5-(3-trifluoroacetamido-1-propynyl)cytosine

생성물 1

HCID 198763381-(2-Hydroxyethoxymethyl)5-(3-amino-1-propynyl)cytosine

실험 절차

The hydroxyl group of the sugar part of alkynylamino nucleoside 69 (0.167 mmol) was converted to a triphosphate and the trifluoroacetyl group was removed following the general procedure given in Example 1E. After addition of the second aliquot of phosphorus oxychloride, phosphorylation was allowed to proceed for for 75 min. Assuming an absorption coefficient for the product equal to that of the starting material (7,790), the yield of triphosphate 67, based on its UV absorption at 291 nm, was 21%.

후처리

  1. customthe trifluoroacetyl group was removed
  2. additionAfter addition of the second aliquot of phosphorus oxychloride, phosphorylation
  3. customto proceed for for 75 min
  4. customthe yield of triphosphate 67, based on its UV absorption at 291 nm

출처 및 근거

ORD 기록
ord-af9848824da5406e80396e01c8eacb82
출처 데이터셋
uspto-grants-1992_09
특허 번호
US05151507

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