Thionyl Chloride → 1-(1-Chloroethyl)naphthalene

HRID 1886527

반응식

HRID 1886527 반응식
[C:1]1([CH:11](O)[CH3:12])[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[CH:4]=[CH:3][CH:2]=1.S(Cl)([Cl:16])=O>C1(C)C=CC=CC=1>[C:1]1([CH:11]([Cl:16])[CH3:12])[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[CH:4]=[CH:3][CH:2]=1

참가 물질

4

반응물 2

HCID 24386Thionyl ChlorideHCID 980301-(1-Naphthyl)ethanol

생성물 1

HCID 132442811-(1-Chloroethyl)naphthalene

시약·촉매·용매 1

HCID 1140Toluene용매

실험 절차

A solution of 1-(1-naphthalyl)ethanol (6.34 g, 38.8 mmol) and thionyl chloride (5.37 ml, 73.6 mmol) in 65 ml of toluene was refluxed for 4 hours. The reaction mixture was evaporated to give the residue as an oil. The residue was dissolved in 150 ml of ethyl acetate, washed successively with 50 ml of water, 50 ml of saturated sodium bicarbonate and 50 ml of brine, and dried over sodium sulfate. The solvent was removed in vacuo to give 3(6.83 g, 97%) as an oil.

후처리

  1. customThe reaction mixture was evaporated

출처 및 근거

ORD 기록
ord-aeeee3d783ad454c8ab37aa78190e494
출처 데이터셋
uspto-grants-1992_09
특허 번호
US05151526

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