Pyridine → N-(2-hydroxy-5-nitrophenyl)butanamide

HRID 1886954

반응식

HRID 1886954 반응식
[NH2:1][C:2]1[CH:7]=[C:6]([N+:8]([O-:10])=[O:9])[CH:5]=[CH:4][C:3]=1[OH:11].N1C=CC=CC=1.[C:18](Cl)(=[O:22])[CH2:19][CH2:20][CH3:21]>ClCCl>[OH:11][C:3]1[CH:4]=[CH:5][C:6]([N+:8]([O-:10])=[O:9])=[CH:7][C:2]=1[NH:1][C:18](=[O:22])[CH2:19][CH2:20][CH3:21]

참가 물질

5

반응물 3

HCID 1049PyridineHCID 8855Butyryl chlorideHCID 36133892-Amino-4-Nitrophenol

생성물 1

HCID 3599768N-(2-hydroxy-5-nitrophenyl)butanamide수율 34%

시약·촉매·용매 1

HCID 6344Dichloromethane용매

실험 절차

To a solution of 2-amino-4-nitrophenol (10 g, 64.9 mmol) in dichloromethane (250 mL) under nitrogen at 0° C. was added pyridine (10.5 mL, 129.9 mmol) followed by butyryl chloride (7.05 mL, 68.2 mmol) over a period of 5 min. After 30 min at 0° C., the solution was left warming up to room temperature for 2 days. The organic layer was washed with aqueous copper sulfate solution and brine. Insoluble material from the aqueous layer was filtered off and washed with water to afford 4.95 g (34%) of the title compound.

후처리

  1. waitthe solution was left
  2. washThe organic layer was washed with aqueous copper sulfate solution and brine
  3. filtrationInsoluble material from the aqueous layer was filtered off
  4. washwashed with water

출처 및 근거

ORD 기록
ord-ec65866deaea4f778d6801b4cbdddc5a
출처 데이터셋
uspto-grants-2013_08
특허 번호
US08501713B2

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