Ethanol → Ethyl (2-aminoethyl)(methyl)phosphinate

HRID 1886999노트

반응식

HRID 1886999 반응식
[CH2:1]([O:3][P:4]([CH2:7][CH2:8][NH:9]C(OCC1C=CC=CC=1)=O)([CH3:6])=[O:5])[CH3:2].CCO>[Pd].CCOC(C)=O>[CH2:1]([O:3][P:4]([CH2:7][CH2:8][NH2:9])([CH3:6])=[O:5])[CH3:2]

참가 물질

5

반응물 2

HCID 702EthanolHCID 67033999(2-Benzyloxycarbonylamino-ethyl)-methyl-phosphinic acid ethyl ester

생성물 1

HCID 85676205Ethyl (2-aminoethyl)(methyl)phosphinate수율 90%

시약·촉매·용매 2

HCID 23938Palladium촉매HCID 8857Ethyl Acetate용매

실험 절차

(2-Benzyloxycarbonylamino-ethyl)-methyl-phosphinic acid ethyl ester (1.3 g, 4.56 mmol) and 10% Pd/C (485 mg) were combined in a flask and EtOH (46 mL) was added. The reaction flask atmosphere was exchanged for H2 and the reaction was run at room temperature until complete, as determined by TLC (eluent: 100% EtOAc). The reaction was then filtered through Supercell NF and the filtrate was concentrated to yield (2-amino-ethyl)-methyl-phosphinic acid ethyl ester (615 mg, 90%) as a yellow oil in which white crystals began to form under high vacuum.

후처리

  1. customwas run at room temperature
  2. filtrationThe reaction was then filtered through Supercell NF
  3. concentrationthe filtrate was concentrated

출처 및 근거

ORD 기록
ord-c96f73aeb964487aa33ffdb38e1e0127
출처 데이터셋
uspto-grants-2013_08
특허 번호
US08501714B2

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