Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Trimethylamine → 1-benzyl-3-(BOC-amino)-3-trifluoromethylpyrrolidine
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Trimethylamine | HCID 1146 | — |
| 반응물 | tert-Butanol | HCID 6386 | — |
| 반응물 | P,P-Diphenylphosphinic azide | HCID 199401 | — |
| 반응물 | 1-Benzyl-3-(trifluoromethyl)pyrrolidine-3-carboxylic acid | HCID 19691367 | — |
| 생성물 | 1-benzyl-3-(BOC-amino)-3-trifluoromethylpyrrolidine | HCID 19691488 | 96.7% |
반응 단계
A mixture of 1.42 g of the compound from step 454a, 1.71 g of diphenylphosphoryl azide, 12.3 g of t-butanol and 0.627 g of trimethyl amine was heated at reflux under N2 for 24 hours. The mixture was concentrated to dryness, and the residue was dissolved in methylene chloride. The solution was washed with satd. NaHCO3 and water, then concentrated. The residue was chromatographed on silica gel to give 1.73 g of the title compound.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US05726182 |
| 출처 데이터셋 | uspto-grants-1998_03 |
| ORD ID | ord-3c14aa7c3cf94af8afc09046f03b475b |
| 출처 메모 | uspto-grants-1998_03 |