Boron tribromide → 6-Hydroxy-4-(4,4,4-trifluoro-butyl)-isoquinoline

HRID 1887085

반응식

HRID 1887085 반응식
C[O:2][C:3]1[CH:4]=[C:5]2[C:10](=[CH:11][CH:12]=1)[CH:9]=[N:8][CH:7]=[C:6]2[CH2:13][CH2:14][CH2:15][C:16]([F:19])([F:18])[F:17].B(Br)(Br)Br.BrC1C=C2C(C=CN=C2)=CC=1O>>[OH:2][C:3]1[CH:4]=[C:5]2[C:10](=[CH:11][CH:12]=1)[CH:9]=[N:8][CH:7]=[C:6]2[CH2:13][CH2:14][CH2:15][C:16]([F:19])([F:17])[F:18]

참가 물질

4

반응물 3

HCID 25134Boron tribromideHCID 576470536-Methoxy-4-(4,4,4-trifluoro-butyl)-isoquinolineHCID 1358548376-Isoquinolinol, 7-bromo-

생성물 1

HCID 1360928996-Hydroxy-4-(4,4,4-trifluoro-butyl)-isoquinoline수율 42.4%

실험 절차

1.02 g of 6-Methoxy-4-(4,4,4-trifluoro-butyl)-isoquinoline (87) were treated with boron tribromide as described for the synthesis of compound 1 to give 410 mg of the desired product 88. LCMS Method # 1, retention time 1.04 min, detected mass 256.00 [M+H]+

출처 및 근거

ORD 기록
ord-b3ee4ab09bab40819a0ef29c1f391716
출처 데이터셋
uspto-grants-2013_08
특허 번호
US08501736B2

연결된 노트

불러오는 중…