Water → HCID 67503155, 화합물

HRID 1887199노트

반응식

HRID 1887199 반응식
[C:1]([O:5][C:6](=[O:20])[C@@H:7]([NH:10][C:11]([C:13]1[C:18]([NH2:19])=[CH:17][CH:16]=[CH:15][N:14]=1)=[O:12])[CH2:8][CH3:9])([CH3:4])([CH3:3])[CH3:2].[C:21](N1C=CN=C1)(N1C=CN=C1)=[O:22].N12CCCN=C1CCCCC2.O>O1CCCC1>[C:1]([O:5][C:6](=[O:20])[C@@H:7]([N:10]1[C:11](=[O:12])[C:13]2[N:14]=[CH:15][CH:16]=[CH:17][C:18]=2[NH:19][C:21]1=[O:22])[CH2:8][CH3:9])([CH3:2])([CH3:3])[CH3:4]

참가 물질

6

반응물 4

HCID 962WaterHCID 682631,1'-CarbonyldiimidazoleHCID 811841,8-Diazabicyclo(5.4.0)undec-7-eneHCID 67502797HCID 67502797, 화합물

생성물 1

HCID 67503155HCID 67503155, 화합물수율 55%

시약·촉매·용매 1

HCID 8028Tetrahydrofuran용매

실험 절차

A solution of 217 mg of (S)-2-[(3-amino-pyridine-2-carbonyl)-amino]-butyric acid tert-butyl ester in tetrahydrofuran (10 mL) is treated with 259 mg of 1,1′-carbonyldiimidazole and 0.018 mL of 1,8-diazabicyclo[5.4.0]undec-7-ene. The mixture is stirred at room temperature for 16 h. Then the reaction mixture is added water (1 mL) and the resulting mixture is concentrated and purified by flash chromatography on silica gel to give 130 mg (55%) of (S)-2-(2,4-dioxo-1,4-dihydro-2H-pyrido[3,2-d]pyrimidin-3-yl)-butyric acid tert-butyl ester.

후처리

  1. concentrationthe resulting mixture is concentrated
  2. custompurified by flash chromatography on silica gel

출처 및 근거

ORD 기록
ord-e2c1fd4d254b4278b2b97c065f81029a
출처 데이터셋
uspto-grants-2013_08
특허 번호
US08501749B2

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