Potassium Carbonate → HCID 67502537, 화합물

HRID 1887200노트

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HRID 1887200 반응식
[C:1]([O:5][C:6](=[O:22])[C@@H:7]([N:10]1[C:15](=[O:16])[C:14]2[N:17]=[CH:18][CH:19]=[CH:20][C:13]=2[NH:12][C:11]1=[O:21])[CH2:8][CH3:9])([CH3:4])([CH3:3])[CH3:2].Br[CH2:24][C:25]1[C:29]2[C:30]([CH3:35])=[CH:31][C:32]([CH3:34])=[CH:33][C:28]=2[S:27][N:26]=1.C(=O)([O-])[O-].[K+].[K+]>O>[C:1]([O:5][C:6](=[O:22])[C@@H:7]([N:10]1[C:15](=[O:16])[C:14]2[N:17]=[CH:18][CH:19]=[CH:20][C:13]=2[N:12]([CH2:24][C:25]2[C:29]3[C:30]([CH3:35])=[CH:31][C:32]([CH3:34])=[CH:33][C:28]=3[S:27][N:26]=2)[C:11]1=[O:21])[CH2:8][CH3:9])([CH3:2])([CH3:3])[CH3:4]

참가 물질

5

반응물 3

HCID 11430Potassium CarbonateHCID 584973913-Bromomethyl-4,6-dimethyl-benzo[d]isothiazoleHCID 67503155HCID 67503155, 화합물

생성물 1

HCID 67502537HCID 67502537, 화합물수율 99.4%

시약·촉매·용매 1

HCID 962Water용매

실험 절차

A mixture of 46 mg of (S)-2-(2,4-dioxo-1,4-dihydro-2H-pyrido[3,2-d]pyrimidin-3-yl)-butyric acid tert-butyl ester, 41 mg of 3-bromomethyl-4,6-dimethyl-1,2-benzoisothiazole and 111 mg of potassium carbonate is stirred at room temperature for 4 h. The reaction mixture is diluted with water and the product is filtered and washed with water. The isolated solid is purified by flash chromatography on silica gel to give 72 mg (99%) of (S)-2-[1-(4,6-dimethyl-benzo[d]isothiazol-3-ylmethyl)-2,4-dioxo-1,4-dihydro-2H-pyrido[3,2-d]pyrimidin-3-yl]-butyric acid tert-butyl ester.

후처리

  1. filtrationthe product is filtered
  2. washwashed with water
  3. customThe isolated solid is purified by flash chromatography on silica gel

출처 및 근거

ORD 기록
ord-29684024931340509b8319ffc0404d0d
출처 데이터셋
uspto-grants-2013_08
특허 번호
US08501749B2

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