Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Cesium carbonate → Trifluoroacetic acid
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Cesium carbonate | HCID 10796 | — |
| 반응물 | 2-Methoxy-4-morpholinoaniline | HCID 414960 | — |
| 반응물 | 1,1'-(9,9-Dimethyl-9H-xanthene-4,5-diyl)bis(1,1-diphenylphosphine) | HCID 636044 | — |
| 반응물 | N-(2-chloro-5-(trifluoromethyl)pyridin-4-yl)pyridin-2-amine | HCID 58155070 | — |
| 촉매 | Bis(dibenzylideneacetone)palladium | HCID 9811564 | — |
| 용매 | 1,4-Dioxane | HCID 31275 | — |
| 생성물 | Trifluoroacetic acid | HCID 6422 | — |
| 생성물 | N2-(2-methoxy-4-morpholinophenyl)-N4-(pyridin-2-yl)-5-(trifluoromethyl)pyridine-2,4-diamine | HCID 24938452 | — |
반응 단계
Method A was applied to a mixture of N-(2-chloro-5-(trifluoromethyl)pyridin-4-yl)pyridin-2-amine (16 mg, 0.059 mmol), 2-methoxy-4-morpholinoaniline (17 mg, 0.082 mmol), Pd2(dba)3 (6 mg, 0.0066 mmol), xantphos (5.5 mg, 0.0095 mmol) and cesium carbonate (43 mg, 0.13 mmol) in dioxane (3 ml). The bis-TFA salt of the title compound was obtained as a yellow solid.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US08501763B2 |
| 출처 데이터셋 | uspto-grants-2013_08 |
| ORD ID | ord-9359eecd6d9647209b33bfacdc01cf7d |
| 출처 메모 | uspto-grants-2013_08 |