4,5-difluoro-N-methyl-2-nitrobenzamide → HCID 57974170, 화합물

HRID 1887699노트

반응식

HRID 1887699 반응식
[F:1][C:2]1[C:11]([F:12])=[CH:10][C:5]([C:6]([NH:8][CH3:9])=[O:7])=[C:4]([N+:13]([O-])=O)[CH:3]=1.[H][H]>CO.[Pd]>[NH2:13][C:4]1[CH:3]=[C:2]([F:1])[C:11]([F:12])=[CH:10][C:5]=1[C:6]([NH:8][CH3:9])=[O:7]

참가 물질

5

반응물 2

HCID 619939344,5-difluoro-N-methyl-2-nitrobenzamideHCID 178418361HCID 178418361, 화합물2회

생성물 1

HCID 57974170HCID 57974170, 화합물

시약·촉매·용매 2

HCID 23938Palladium촉매HCID 887Methanol용매

실험 절차

To 4,5-difluoro-N-methyl-2-nitrobenzamide (1.33 g, 6.15 mmol) in methanol (50 mL) was added Pd/C (10% Pd in carbon, 200 mg, 15 wt %) under argon. A hydrogen balloon was used as hydrogen source. The reaction was stirred at room temperature overnight. The mixture was filtered through celite and the celite pad was washed several times. The solvent was removed the crude was purified by silica gel chromatography to obtain the desired product (quantitative yield).

후처리

  1. filtrationThe mixture was filtered through celite
  2. washthe celite pad was washed several times
  3. customThe solvent was removed the crude
  4. customwas purified by silica gel chromatography

출처 및 근거

ORD 기록
ord-c3b9679742b84d70a16bb2de293a8d62
출처 데이터셋
uspto-grants-2013_08
특허 번호
US08501763B2

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