Isopropylamine → N-isopropyl-2-nitrobenzenesulfonamide

HRID 1887709노트

반응식

HRID 1887709 반응식
[N+:1]([C:4]1[CH:9]=[CH:8][CH:7]=[CH:6][C:5]=1[S:10](Cl)(=[O:12])=[O:11])([O-:3])=[O:2].[CH:14]([NH2:17])([CH3:16])[CH3:15].CCN(CC)CC>CO>[CH:14]([NH:17][S:10]([C:5]1[CH:6]=[CH:7][CH:8]=[CH:9][C:4]=1[N+:1]([O-:3])=[O:2])(=[O:12])=[O:11])([CH3:16])[CH3:15]

참가 물질

5

반응물 3

HCID 6363IsopropylamineHCID 8471TriethylamineHCID 155402-Nitrobenzenesulfonyl chloride

생성물 1

HCID 4154456N-isopropyl-2-nitrobenzenesulfonamide수율 63%

시약·촉매·용매 1

HCID 887Methanol용매

실험 절차

To the solution of 2-nitrobenzene-1-sulfonyl chloride (1.11 g, 5.0 mmol) in MeOH (30 mL) was added isopropylamine (0.85 mL, 2.0 eq) and Et3N (1.4 mL, 2.0 eq). The mixture was stirred overnight at room temperature. The solvent was removed and the crude was purified by silica gel chromatography to obtain the desired product N-isopropyl-2-nitrobenzenesulfonamide (0.774 g, isolated yield 63%).

후처리

  1. customThe solvent was removed
  2. customthe crude was purified by silica gel chromatography

출처 및 근거

ORD 기록
ord-29352af446574d9ab7712363069a2ad9
출처 데이터셋
uspto-grants-2013_08
특허 번호
US08501763B2

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