N-isopropyl-2-nitrobenzenesulfonamide → 2-Amino-N-isopropylbenzenesulfonamide

HRID 1887710노트

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HRID 1887710 반응식
[CH:1]([NH:4][S:5]([C:8]1[CH:13]=[CH:12][CH:11]=[CH:10][C:9]=1[N+:14]([O-])=O)(=[O:7])=[O:6])([CH3:3])[CH3:2].[H][H]>CO.[Pd]>[NH2:14][C:9]1[CH:10]=[CH:11][CH:12]=[CH:13][C:8]=1[S:5]([NH:4][CH:1]([CH3:3])[CH3:2])(=[O:7])=[O:6]

참가 물질

5

반응물 2

HCID 4154456N-isopropyl-2-nitrobenzenesulfonamideHCID 178418361HCID 178418361, 화합물2회

생성물 1

HCID 167834652-Amino-N-isopropylbenzenesulfonamide

시약·촉매·용매 2

HCID 23938Palladium촉매HCID 887Methanol용매

실험 절차

To N-isopropyl-2-nitrobenzenesulfonamide (774 mg) in methanol (50 mL) was added Pd/C (10% Pd in carbon, 150 mg, 19 wt %) under argon protection. A hydrogen balloon was used as the hydrogen source. The reaction was stirred at room temperature overnight. The mixture was filtered through celite and the celite pad was washed several times. The solvent was removed and the crude was purified by silica gel chromatography to obtain the desired product 2-amino-N-isopropylbenzenesulfonamide (quantitative yield).

후처리

  1. filtrationThe mixture was filtered through celite
  2. washthe celite pad was washed several times
  3. customThe solvent was removed
  4. customthe crude was purified by silica gel chromatography

출처 및 근거

ORD 기록
ord-ad18248975df4150a1fb470bd327ec34
출처 데이터셋
uspto-grants-2013_08
특허 번호
US08501763B2

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