Chloroacetyl chloride → 2-Chloro-N-methyl-N-(4-nitro-phenyl)-acetamide

HRID 1887714노트

반응식

HRID 1887714 반응식
[Cl:1][CH2:2][C:3](Cl)=[O:4].[CH3:6][NH:7][C:8]1[CH:13]=[CH:12][C:11]([N+:14]([O-:16])=[O:15])=[CH:10][CH:9]=1.[OH-].[K+]>CCOC(C)=O.O>[Cl:1][CH2:2][C:3]([N:7]([CH3:6])[C:8]1[CH:9]=[CH:10][C:11]([N+:14]([O-:16])=[O:15])=[CH:12][CH:13]=1)=[O:4]

참가 물질

6

반응물 3

HCID 6577Chloroacetyl chlorideHCID 7483N-Methyl-4-nitroanilineHCID 14797Potassium Hydroxide

생성물 1

HCID 114361292-Chloro-N-methyl-N-(4-nitro-phenyl)-acetamide

시약·촉매·용매 2

HCID 962Water용매HCID 8857Ethyl Acetate용매

반응 조건

온도
0 °C

실험 절차

Chloroacetyl chloride (1.05 mL, 13.1 mmol) is added in one portion to a biphasic mixture of N-methyl-4-nitroaniline (1.0 g, 6.57 mmol), KOH (1.11 g, 19.7 mmol) in 12 mL EtOAc and 12 mL H2O, cooled to 0° C. The resulting mixture is stirred at this temperature for 5 min, then the ice bath was removed and it was allowed to warm to RT. The reaction was stirred for an additional one hour at RT.

후처리

  1. customthe ice bath was removed
  2. temperatureto warm to RT
  3. stirringThe reaction was stirred for an additional one hour at RT

출처 및 근거

ORD 기록
ord-7ea943c4ff404856983585c5322e5957
출처 데이터셋
uspto-grants-2013_08
특허 번호
US08501763B2

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