2-Pyrrolidin-1-yl-isonicotinic acid → HCID 71208441, 화합물

반응식

[NH2:1][CH2:2][C:3]1[C:12](=[O:13])[C:11]2[C:6](=[CH:7][C:8]([Cl:14])=[CH:9][CH:10]=2)[N:5]([C:15]2[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=2)[CH:4]=1.[N:21]1([C:26]2[CH:27]=[C:28]([CH:32]=[CH:33][N:34]=2)[C:29](O)=[O:30])[CH2:25][CH2:24][CH2:23][CH2:22]1>>[Cl:14][C:8]1[CH:7]=[C:6]2[C:11]([C:12](=[O:13])[C:3]([CH2:2][NH:1][C:29](=[O:30])[C:28]3[CH:32]=[CH:33][N:34]=[C:26]([N:21]4[CH2:22][CH2:23][CH2:24][CH2:25]4)[CH:27]=3)=[CH:4][N:5]2[C:15]2[CH:16]=[CH:17][CH:18]=[CH:19][CH:20]=2)=[CH:10][CH:9]=1

참가 물질

반응물 2

HCID 64842362-Pyrrolidin-1-yl-isonicotinic acid

HCID 712083983-(aminomethyl)-7-chloro-1-phenylquinolin-4(1H)-one

생성물 1

HCID 71208441HCID 71208441, 화합물

실험 절차

N-(7-Chloro-4-oxo-1-phenyl-1,4-dihydro-quinolin-3-ylmethyl)-2-pyrrolidin-1-yl-iso-nicotinamide was prepared starting from intermediate D and 2-(pyrrolidin-1-yl)isonicotinic acid. MS calcd. for C26H24ClN4O2 [(M+H)+] 459.2, obsd. 459.0.

출처 및 근거

ORD 기록: ord-82de916d25a8449b9263e2a2bd98d92b
출처 데이터셋: uspto-grants-2013_08
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US08501732B2

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