2,5-Difluorobenzoyl chloride → HCID 71208641, 화합물

반응식

[NH2:1][CH2:2][C:3]1[C:12](=[O:13])[C:11]2[C:6](=[CH:7][C:8]([Cl:14])=[CH:9][CH:10]=2)[N:5]([C:15]2[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=2)[CH:4]=1.[F:21][C:22]1[CH:30]=[CH:29][C:28]([F:31])=[CH:27][C:23]=1[C:24](Cl)=[O:25]>>[Cl:14][C:8]1[CH:7]=[C:6]2[C:11]([C:12](=[O:13])[C:3]([CH2:2][NH:1][C:24](=[O:25])[C:23]3[CH:27]=[C:28]([F:31])[CH:29]=[CH:30][C:22]=3[F:21])=[CH:4][N:5]2[C:15]2[CH:16]=[CH:17][CH:18]=[CH:19][CH:20]=2)=[CH:10][CH:9]=1

참가 물질

반응물 2

HCID 5880822,5-Difluorobenzoyl chloride

HCID 712083983-(aminomethyl)-7-chloro-1-phenylquinolin-4(1H)-one

생성물 1

HCID 71208641HCID 71208641, 화합물

실험 절차

N-(7-Chloro-4-oxo-1-phenyl-1,4-dihydro-quinolin-3-ylmethyl)-2,5-difluoro-benzamide was prepared starting from intermediate D and 2,5-difluoro-benzoyl chloride. 1H NMR (400 MHz, DMSO-d6) δ ppm 8.70 (br. s., 1H) 8.28 (d, J=8.66 Hz, 1H) 8.00 (s, 1H) 7.53-7.79 (m, 5 H) 7.21-7.52 (m, 4H) 6.92 (d, J=1.81 Hz, 1H) 4.39 (d, J=5.64 Hz, 2H).

출처 및 근거

ORD 기록: ord-6807af82f885459896574f0a499d9dcf
출처 데이터셋: uspto-grants-2013_08
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US08501732B2

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