Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Donepezil → Donepezil methanesulfonate
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Donepezil | HCID 3152 | — |
| 반응물 | Methanesulfonic Acid | HCID 6395 | — |
| 반응물 | Propyl ether | HCID 8114 | — |
| 용매 | Ethanol | HCID 702 | — |
| 생성물 | Donepezil methanesulfonate | HCID 131730793 | — |
반응 단계
Methanesulfonic acid (1.3 ml, dissolved in 11 ml of absolute ethanol) is slowly added to a solution of Donepezil (3.79 g) in absolute ethanol (38 ml) with stirring at room temperature, and 50 ml of dipropyl ether is added. The solid precipitated is filtered and dried at 55° C. under vacuum to give the title compound. Melting point: 180.3° C.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US08501779B2 |
| 출처 데이터셋 | uspto-grants-2013_08 |
| ORD ID | ord-2dc43549994e4f18bcf31875780ac882 |
| 출처 메모 | uspto-grants-2013_08 |