Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Donepezil → Donepezil Maleate
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Donepezil | HCID 3152 | — |
| 반응물 | Propyl ether | HCID 8114 | — |
| 반응물 | Maleic Acid | HCID 444266 | — |
| 용매 | Ethyl Acetate | HCID 8857 | — |
| 생성물 | Donepezil Maleate | HCID 24801486 | — |
반응 단계
Maleic acid (1.161 g, dissolved in 10 ml of 2-propanol) is slowly added to a solution of Donepezil (3.79 g) in ethyl acetate (20 ml) with stirring at room temperature followed by adding 10 ml of dipropyl ether. The solid precipitated is filtered and dried at 55° C. under vacuum to give the title compound. Melting point: 126.8° C.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US08501779B2 |
| 출처 데이터셋 | uspto-grants-2013_08 |
| ORD ID | ord-32da11b15fde4c9cb03ca14a19bc2d79 |
| 출처 메모 | uspto-grants-2013_08 |