Sodium Iodide → HCID 67119908, 화합물

HRID 1888086노트

반응식

HRID 1888086 반응식
[Cl-:1].[Ce+3].[Cl-].[Cl-].[I-].[Na+].Br[CH2:8][C:9]([C:11]1[CH:16]=[CH:15][C:14]([N:17]2[CH2:22][CH2:21][O:20][CH2:19][CH2:18]2)=[CH:13][CH:12]=1)=[O:10].[CH2:23]([N:30]1[CH2:35][CH2:34][C:33](=[O:36])[CH2:32][CH2:31]1)[C:24]1[CH:29]=[CH:28][CH:27]=[CH:26][CH:25]=1>O1CCCC1>[ClH:1].[CH2:23]([N:30]1[CH2:35][CH2:34][C:33]([CH2:8][C:9](=[O:10])[C:11]2[CH:16]=[CH:15][C:14]([N:17]3[CH2:22][CH2:21][O:20][CH2:19][CH2:18]3)=[CH:13][CH:12]=2)([OH:36])[CH2:32][CH2:31]1)[C:24]1[CH:25]=[CH:26][CH:27]=[CH:28][CH:29]=1

참가 물질

6

반응물 4

HCID 5238Sodium IodideHCID 192201-Benzyl-4-piperidoneHCID 24636Cerium(III) chlorideHCID 27953572-Bromo-1-(4-morpholinophenyl)ethanone

생성물 1

HCID 67119908HCID 67119908, 화합물수율 40%

시약·촉매·용매 1

HCID 8028Tetrahydrofuran용매2회

실험 절차

Anhydrous cerium chloride (0.99 g, 4.0 mmol) and sodium iodide (1.8 g, 12.0 mmol) are added to 10 ml of anhydrous tetrahydrofuran as a solvent to form a suspension. Dissolving 1.07 g (4.0 mmol) of 2-bromo-1-(4-morpholinophenyl)ethanone and 0.76 g (4.0 mmol) of N-benzyl-4-piperidone into 10 ml of anhydrous tetrahydrofuran, and the solution is added dropwise to the above suspension and reacting at room temperature for 2 hours. Operating according to the post-treatment procedure in General Method three to obtain 0.69 g of a white crystal, with yield of 34.3%.

후처리

  1. customto form a suspension
  2. additionthe solution is added dropwise to the above suspension

출처 및 근거

ORD 기록
ord-7be1c0ae7f014ef6994d40a10ad680e3
출처 데이터셋
uspto-grants-2013_08
특허 번호
US08501778B2

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