Trifluoroacetic acid → HCID 178509434, 화합물

HRID 1888211노트

반응식

HRID 1888211 반응식
[Br:1][C:2]1[CH:3]=[C:4]2[C:8](=[C:9]([C:11]#[N:12])[CH:10]=1)[NH:7][N:6]=[C:5]2[CH:13]1[CH2:18][CH2:17][N:16](C(OC(C)(C)C)=O)[CH2:15][CH2:14]1.FC(F)(F)C(O)=O>ClCCl>[Br:1][C:2]1[CH:3]=[C:4]2[C:8](=[C:9]([C:11]#[N:12])[CH:10]=1)[NH:7][N:6]=[C:5]2[CH:13]1[CH2:18][CH2:17][NH:16][CH2:15][CH2:14]1

참가 물질

4

반응물 2

HCID 6422Trifluoroacetic acidHCID 178451811HCID 178451811, 화합물2회

생성물 1

HCID 178509434HCID 178509434, 화합물수율 147.6%

시약·촉매·용매 1

HCID 6344Dichloromethane용매

실험 절차

A solution of 1,1-dimethylethyl 4-(5-bromo-7-cyano-1H-indazol-3-yl)-1-piperidine-carboxylate (Intermediate 3) (0.200 g, 0.493 mmols) and trifluoroacetic acid (0.25 mL) in dichloromethane (5 mL) was stirred at room temperature for 2 hrs. The solution was cooled and the solvent removed in vacuo to give the crude amine (222 mg) trifluoroacetate salt, which was used in the next step without further purification.

후처리

  1. temperatureThe solution was cooled
  2. customthe solvent removed in vacuo

출처 및 근거

ORD 기록
ord-fb808721c9014c93b9d0ec8234f112cf
출처 데이터셋
uspto-grants-2013_08
특허 번호
US08501780B2

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