4-t-Butylbenzenesulfonyl chloride → 4-tert-Butyl-N-[4-chloro-2-(4-fluoro-benzoyl)-phenyl]benzenesulfonamide

HRID 18885

반응식

HRID 18885 반응식
[NH2:1][C:2]1[CH:7]=[CH:6][C:5]([Cl:8])=[CH:4][C:3]=1[C:9]([C:11]1[CH:16]=[CH:15][C:14]([F:17])=[CH:13][CH:12]=1)=[O:10].[C:18]([C:22]1[CH:27]=[CH:26][C:25]([S:28](Cl)(=[O:30])=[O:29])=[CH:24][CH:23]=1)([CH3:21])([CH3:20])[CH3:19]>>[C:18]([C:22]1[CH:27]=[CH:26][C:25]([S:28]([NH:1][C:2]2[CH:7]=[CH:6][C:5]([Cl:8])=[CH:4][C:3]=2[C:9](=[O:10])[C:11]2[CH:16]=[CH:15][C:14]([F:17])=[CH:13][CH:12]=2)(=[O:30])=[O:29])=[CH:24][CH:23]=1)([CH3:21])([CH3:19])[CH3:20]

참가 물질

3

반응물 2

HCID 1398824-t-Butylbenzenesulfonyl chlorideHCID 109559554-Chloro-2-(4-fluorobenzoyl)aniline

생성물 1

HCID 113053784-tert-Butyl-N-[4-chloro-2-(4-fluoro-benzoyl)-phenyl]benzenesulfonamide

실험 절차

The title compound was prepared according to the general procedure for the synthesis of N-Aryl-benzenesulfonamides previously desribed using 125 mg of (2-Amino-5-chloro-phenyl)-(4-fluoro-phenyl)-methanone and 116 mg of 4-tert-butyl-benzenesulfonyl chloride. 1H-NMR (400 MHz, CDCl3): δ 1.21 (s, 9H), 7.09 (t, 2H, J=NMR 8.8 Hz), 7.29 (m, 3H), 7.43-7.50 (m, 3H), 7.59 (m, 2H), 7.77 (d, 1H, J=8.8 Hz), 9.72 (s, 1H). MS: m/z 446.0 (M++1).

출처 및 근거

ORD 기록
ord-b977198e06e948ea953f7d2ce406537b
출처 데이터셋
uspto-grants-2010_06
특허 번호
US07741519B2

연결된 노트

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