Potassium Carbonate → 5-(Methylthio)-2-pyridinecarbonitrile

HRID 1888828노트

반응식

HRID 1888828 반응식
Br[C:2]1[CH:3]=[CH:4][C:5]([C:8]#[N:9])=[N:6][CH:7]=1.[CH3:10][S-:11].[Na+].C(=O)([O-])[O-].[K+].[K+]>CN1C(=O)CCC1>[CH3:10][S:11][C:2]1[CH:3]=[CH:4][C:5]([C:8]#[N:9])=[N:6][CH:7]=1

참가 물질

5

반응물 3

HCID 11430Potassium CarbonateHCID 8171545-Bromopyridine-2-carbonitrileHCID 4378561Sodium methanethiolate

생성물 1

HCID 594558745-(Methylthio)-2-pyridinecarbonitrile수율 99%

시약·촉매·용매 1

HCID 13387N-methyl-2-pyrrolidone용매

실험 절차

5-Bromo-pyridine-2-carbonitrile (2.63 g, 13.7 mmol), sodium methanethiolate (1.44 g, 20.5 mmol), potassium carbonate (3.79 g, 27.4 mmol) in NMP (60 ml) were stirred in a sealed flask overnight. The mixture was partitioned between ethyl acetate and water. The organic phase was washed with water several times, brine and dried over sodium sulphate. The solvent was removed in vacuo to afford the title compound as a yellow solid (2.0 g, 99%).

후처리

  1. customThe mixture was partitioned between ethyl acetate and water
  2. washThe organic phase was washed with water several times, brine
  3. dry with materialdried over sodium sulphate
  4. customThe solvent was removed in vacuo

출처 및 근거

ORD 기록
ord-a3952b42ccca478c9d3fcb39b8d2006e
출처 데이터셋
uspto-grants-2013_08
특허 번호
US08501784B2

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