Hydrazine → 4-Methyl-1,3-thiazole-2-carbohydrazide

참여 물질

반응 단계

A solution of ethyl 4-methyl-1,3-thiazole-2-carboxylate (I120) (208 mg, 1.215 mmol) in ethanol (6.028 ml) was stirred at room temperature under an atmosphere of argon. Hydrazine (0.046 ml, 1.458 mmol) was added and the solution was heated to reflux for 18 hours. The solution was cooled to room temperature and then the solvent was removed under reduced pressure to give a pale yellow coloured solid of desired product in 115 mg.

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