Triethyloxonium tetrafluoroborate → HCID 178519592, 화합물

HRID 1889093노트

반응식

HRID 1889093 반응식
F[B-](F)(F)F.C([O+](CC)CC)C.[Cl:13][C:14]1[C:19]([F:20])=[C:18]([Cl:21])[CH:17]=[CH:16][C:15]=1[C:22]([N:24]1[CH2:29][CH2:28][NH:27][C:26](=O)[CH2:25]1)=[O:23].[OH:31][C:32]1[C:37]([C:38]([NH:40][NH2:41])=O)=[CH:36][CH:35]=[CH:34][N:33]=1>ClCCl>[Cl:13][C:14]1[C:19]([F:20])=[C:18]([Cl:21])[CH:17]=[CH:16][C:15]=1[C:22]([N:24]1[CH2:29][CH2:28][N:27]2[C:38]([C:37]3[C:32]([OH:31])=[N:33][CH:34]=[CH:35][CH:36]=3)=[N:40][N:41]=[C:26]2[CH2:25]1)=[O:23]

참가 물질

5

반응물 3

HCID 2723982Triethyloxonium tetrafluoroborateHCID 665993614-[(2,4-Dichloro-3-fluorophenyl)carbonyl]-2-piperazinoneHCID 178514420HCID 178514420, 화합물

생성물 1

HCID 178519592HCID 178519592, 화합물

시약·촉매·용매 1

HCID 6344Dichloromethane용매

실험 절차

Triethyloxonium tetrafluoroborate (215 mg, 1.134 mmol) was added under argon to a solution of 4-[(2,4-dichloro-3-fluorophenyl)carbonyl]-2-piperazinone (I37) (300 mg, 1.031 mmol) in Dichloromethane (DCM) (2.5 mL). The mixture was stirred at room temperature for 1 h 15 min—after 55 min, the mixture became clear. 2-Hydroxy-3-pyridinecarbohydrazide (I92) (189 mg, 1.237 mmol) was added to the solution and the mixture was stirred at room temperature for one day. The solvent was evaporated under reduced pressure and the residue was dissolved in tert-butanol (2.500 mL).

후처리

  1. stirringthe mixture was stirred at room temperature for one day
  2. customThe solvent was evaporated under reduced pressure
  3. dissolutionthe residue was dissolved in tert-butanol (2.500 mL)

출처 및 근거

ORD 기록
ord-ba7172281dc548da922454406fcf4914
출처 데이터셋
uspto-grants-2013_08
특허 번호
US08501946B2

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