Ethyl chloroformate → Methyl 2-[(ethoxycarbonyl)amino]-5-ethylthiophene-3-carboxylate
반응식
[NH2:1][C:2]1[S:3][C:4]([CH2:11][CH3:12])=[CH:5][C:6]=1[C:7]([O:9][CH3:10])=[O:8].Cl[C:14]([O:16][CH2:17][CH3:18])=[O:15]>C1(C)C=CC=CC=1>[CH2:17]([O:16][C:14]([NH:1][C:2]1[S:3][C:4]([CH2:11][CH3:12])=[CH:5][C:6]=1[C:7]([O:9][CH3:10])=[O:8])=[O:15])[CH3:18]참가 물질
4
반응 조건
- 온도
- 100 °C
실험 절차
A mixture of methyl 2-amino-5-ethylthiophene-3-carboxylate (7.07 g), ethyl chloroformate (4.4 mL) and toluene (100 mL) was stirred at 100° C. for 3 hr. The reaction mixture was concentrated under reduced pressure, and the obtained residue was purified by silica gel column chromatography to give the title compound as colorless oil (9 g, 92%).
후처리
- concentrationThe reaction mixture was concentrated under reduced pressure
- customthe obtained residue was purified by silica gel column chromatography
출처 및 근거
- ORD 기록
- ord-f6cad9811457482fb2f981cfae7d4920
- 출처 데이터셋
- uspto-grants-2013_08
- 특허 번호
- US08501750B2
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