Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Bromotrimethylsilane → Tenofovir
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Bromotrimethylsilane | HCID 76113 | — |
| 반응물 | Diethyl P-(((1R)-2-(6-amino-9H-purin-9-yl)-1-methylethoxy)methyl)phosphonate | HCID 10947889 | — |
| 용매 | Acetonitrile | HCID 6342 | — |
| 생성물 | Tenofovir | HCID 464205 | — |
반응 단계
To a reaction vessel was added stepwise the product (D) of step (4), acetonitrile and Bromotrimethylsilane, the mixture was refluxed while stirring until the completion of the reaction, volatile liquid was removed under vacuum, the resultant residue was then dissolved in a suitable amount of water, and the resulting solution was adjusted to pH 3.0˜3.5 to give the product 9-[(R)-2-(phosphonomethoxy)propyl]adenine (PMPA). Furthermore, dichloromethane or chloroform could be used as reaction solvent and iodotrimethylsilane or chlorotrimethylsilane/potassium iodide as the deprotection agent.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US08507463B2 |
| 출처 데이터셋 | uspto-grants-2013_08 |
| ORD ID | ord-8714acba1ab1429395fcb886b63619c7 |
| 출처 메모 | uspto-grants-2013_08 |