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Cesium carbonate → 5-(benzyloxy)-3-(3-fluoro-2-(trifluoromethyl)phenyl)-3H-imidazo[4,5-b]pyridine

HRID 1890324
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HRID 1890324 반응식
[CH2:1]([O:8][C:9]1[N:14]=[C:13]2[NH:15][CH:16]=[N:17][C:12]2=[CH:11][CH:10]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[F:18][C:19]1[CH:24]=[CH:23][CH:22]=[C:21](F)[C:20]=1[C:26]([F:29])([F:28])[F:27].C([O-])([O-])=O.[Cs+].[Cs+]>CN(C=O)C.CCOCC>[CH2:1]([O:8][C:9]1[N:14]=[C:13]2[N:15]([C:21]3[CH:22]=[CH:23][CH:24]=[C:19]([F:18])[C:20]=3[C:26]([F:27])([F:29])[F:28])[CH:16]=[N:17][C:12]2=[CH:11][CH:10]=1)[C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1
참가 물질반응 조건실험 절차후처리출처 및 근거반응 노트

참가 물질

6

반응물 3

HCID 10796Cesium carbonateHCID 156142331,3-Difluoro-2-(trifluoromethyl)benzeneHCID 178420377HCID 178420377, 화합물

생성물 1

HCID 673123105-(benzyloxy)-3-(3-fluoro-2-(trifluoromethyl)phenyl)-3H-imidazo[4,5-b]pyridine

시약·촉매·용매 2

HCID 3283Diethyl Ether용매
HCID 6228
Dimethylformamide
용매

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온도
80 °C

실험 절차

5-(Benzyloxy)-3H-imidazo[4,5-b]pyridine (0.10 g, 0.44 mmol) and 1,3-difluoro-2-(trifluoromethyl)benzene (0.12 g, 0.67 mmol) were dissolved in DMF (1.0 mL) and Cs2CO3 (0.29 g, 0.89 mmol) was added. The reaction mixture was heated to 80° C. overnight. The solution was then diluted with ether and washed with water. The aqueous layer was back extracted with additional ether. The combined organic portions were washed with brine, dried over MgSO4 and concentrated under reduced pressure to give the title compound.

후처리

  1. washwashed with water
  2. extractionThe aqueous layer was back extracted with additional ether
  3. washThe combined organic portions were washed with brine
  4. dry with materialdried over MgSO4
  5. concentrationconcentrated under reduced pressure

출처 및 근거

ORD 기록
ord-f521f853eeaf48dcb9b1dcfb4838eec1
출처 데이터셋
uspto-grants-2013_08
DOI
10.6084/m9.figshare.5104873.v1
특허 번호
US08507473B2

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