HCID 178526704, 화합물 → HCID 178507771, 화합물
반응식
[CH:1]1([NH:7][C:8]2[N:13]=[C:12]([OH:14])[CH:11]=[CH:10][C:9]=2[N+:15]([O-])=O)[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1>CO.[Pd]>[NH2:15][C:9]1[CH:10]=[CH:11][C:12]([OH:14])=[N:13][C:8]=1[NH:7][CH:1]1[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1참가 물질
4
실험 절차
6-(Cyclohexylamino)-5-nitropyridin-2-ol (0.2 g, 0.843 mmol) was dissolved in methanol (168 mL). Palladium (5% Pd/C, 145 mg, 0.0063 mmol) was added. The reaction was flushed with nitrogen and stirred under a balloon filled with hydrogen for 3 h at room temperature. The reaction was monitored by TLC until the starting materials were consumed. The mixture was filtered through Celite® and concentrated to give the title compound as a dark green solid which was used immediately in next step without further purification.
후처리
- customThe reaction was flushed with nitrogen
- additionfilled with hydrogen for 3 h at room temperature
- customwere consumed
- filtrationThe mixture was filtered through Celite®
- concentrationconcentrated
출처 및 근거
- ORD 기록
- ord-fcfd0c686800469fbeb754eed37849fd
- 출처 데이터셋
- uspto-grants-2013_08
- 특허 번호
- US08507473B2
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