1,1'-Carbonyldiimidazole → HCID 178505196, 화합물

HRID 1890357노트

반응식

HRID 1890357 반응식
[CH3:1][S:2]([O:5][C:6]1[CH:11]=[CH:10][C:9]([NH2:12])=[C:8]([NH:13][CH:14]2[CH2:19][CH2:18][CH2:17][CH2:16][CH2:15]2)[N:7]=1)(=[O:4])=[O:3].C1N=CN([C:25](N2C=NC=C2)=[O:26])C=1>C1COCC1>[CH3:1][S:2]([O:5][C:6]1[N:7]=[C:8]2[N:13]([CH:14]3[CH2:15][CH2:16][CH2:17][CH2:18][CH2:19]3)[C:25]([OH:26])=[N:12][C:9]2=[CH:10][CH:11]=1)(=[O:3])=[O:4]

참가 물질

4

반응물 2

HCID 682631,1'-CarbonyldiimidazoleHCID 866552605-Amino-6-(cyclohexylamino)pyridin-2-yl Methanesulfonate

생성물 1

HCID 178505196HCID 178505196, 화합물수율 61.1%

시약·촉매·용매 1

HCID 8028Tetrahydrofuran용매

반응 조건

온도
70 °C

실험 절차

5-Amino-6-(cyclohexylamino)pyridin-2-yl methanesulfonate (1.44 g, 5.05 mmol) was dissolved in THF (30 mL) and CDI (2.455 g, 15.14 mmol) was added. The mixture was heated at 70° C. for 3 h. THF was removed and the residue was dissolved in EtOAc. The resulting solution was washed with water followed by 1 M HCl, dried over MgSO4 and concentrated under reduced pressure to give the title compound (0.96 g) without further purification. LCMS m/z=312.50 [M+H]+.

후처리

  1. customTHF was removed
  2. dissolutionthe residue was dissolved in EtOAc
  3. washThe resulting solution was washed with water
  4. dry with materialdried over MgSO4
  5. concentrationconcentrated under reduced pressure

출처 및 근거

ORD 기록
ord-d8bd6f6e32274b07b4ba1a291671ebb3
출처 데이터셋
uspto-grants-2013_08
특허 번호
US08507473B2

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