Aluminium lithium hydride → 1-(Thieno[3,2-c]pyridin-2-yl)ethan-1-ol

HRID 1890519노트

반응식

HRID 1890519 반응식
[S:1]1[C:9]2[CH:8]=[CH:7][N:6]=[CH:5][C:4]=2[CH:3]=[C:2]1[C:10](=[O:12])[CH3:11].[H-].[H-].[H-].[H-].[Li+].[Al+3]>C1COCC1>[S:1]1[C:9]2[CH:8]=[CH:7][N:6]=[CH:5][C:4]=2[CH:3]=[C:2]1[CH:10]([OH:12])[CH3:11]

참가 물질

4

반응물 2

HCID 21226445Aluminium lithium hydrideHCID 584330461-(Thieno[3,2-c]pyridin-2-yl)ethanone

생성물 1

HCID 673049441-(Thieno[3,2-c]pyridin-2-yl)ethan-1-ol

시약·촉매·용매 1

HCID 8028Tetrahydrofuran용매

실험 절차

To a solution of 1-(thieno[3,2-c]pyridin-2-yl)ethanone (D′-3) (3.5 g, 1 mmol) in anhydrous THF (50 mL) was added LiAlH4 (1.13 g, 1.5 mmol) in portions at 0° C. The suspension was stirred under this temperature for 1 h. The reaction mixture was quenched with saturated aqueous NH4Cl solution and filtered. The filtrate was washed with brine, concentrated, and then used for the next step without any further purification.

후처리

  1. customThe reaction mixture was quenched with saturated aqueous NH4Cl solution
  2. filtrationfiltered
  3. washThe filtrate was washed with brine
  4. concentrationconcentrated
  5. customused for the next step without any further purification

출처 및 근거

ORD 기록
ord-596329c447e34f76b860f4f8ff482604
출처 데이터셋
uspto-grants-2013_08
특허 번호
US08507487B2

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