Nitrogen → (1H-Pyrrolo[2,3-b]pyridin-2-yl)methanamine
반응식
[NH:1]1[C:5]2=[N:6][CH:7]=[CH:8][CH:9]=[C:4]2[CH:3]=[C:2]1[C:10]([NH2:12])=O.N#N.[H-].[H-].[H-].[H-].[Li+].[Al+3]>C1COCC1>[NH:1]1[C:5]2=[N:6][CH:7]=[CH:8][CH:9]=[C:4]2[CH:3]=[C:2]1[CH2:10][NH2:12]참가 물질
5
반응 조건
- 온도
- 80 °C
실험 절차
To a solution of 1H-pyrrolo[2,3-b]pyridine-2-carboxamide (H-2) (805 mg, 5.0 mmol) in dried THF (10 mL) at 0° C. under 1 atm of N2 was slowly added LiAlH4 (570 mg, 15 mmol). The mixture was stirred at 80° C. overnight. The mixture was then cooled to 0° C. concentrated, and then purified by chromatography on silica gel to afford the title compound (720 mg). MS (m/z): 148 (M+1)+.
후처리
- customat 0° C.
- temperatureThe mixture was then cooled to 0° C.
- concentrationconcentrated
- custompurified by chromatography on silica gel
출처 및 근거
- ORD 기록
- ord-91d2a3ca036643b9a15130922d70ea83
- 출처 데이터셋
- uspto-grants-2013_08
- 특허 번호
- US08507487B2
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